Células troncales mesenquimales de la papila apical y su papel prometedor en la biología radicular

Andrea Juliana Cortés Gaitán, Tatiana Cortés Velosa, Ana Elizabeth Duque Rodriguez, Alvaro Andrés Rodríguez, Juan Carlos Munévar Niño

Resumen


OBJETIVO: En la actualidad, la práctica odontológica ha centrado su atención en terapias regenerativas. Una nueva fuente de células troncales dentales ha sido hallada en la papila apical de dientes permanentes inmaduros humanos, sin embargo, no hay ningún estudio de revisión bibliográfica de esta nueva población celular y su papel prometedor en la biología radicular para posterior aplicación en endodoncia regenerativa. METODOLOGÍA: Se realizó una revisión en la literatura usando bases de datos como PubMed, MEDLINE, Science Direct, entre otras. Se utilizó el algoritmo de búsqueda: (Stem Cells OR Cell, Stem OR Cells, Stem OR Stem Cell OR Progenitor Cells OR Cell, Progenitor OR Cells, Progenitor OR Progenitor Cell OR Mother Cells OR Cell, Mother OR Cells, Mother OR Mother Cell OR Dental Papilla OR Papillae, Dental OR Dental Papillae OR Papilla, Dental) OR Papilla Apical AND Cell Proliferation OR Proliferation, Cell OR Cellular Proliferation OR Proliferation. No hubo restricción de lenguaje ni de sexo. Se buscaron estudios en humanos, y artículos de revisión en los últimos 5 años. RESULTADOS: La búsqueda arrojó 50 artículos de los cuales fueron seleccionados 30 basados en su abstract. CONCLUSIÓN: Es posible obtener y expandir células de la papila apical de dientes permanentes inmaduros con fenotipo de células troncales mesenquimales. Estas células pueden ser viables y son posibles candidatas estándar para ser usadas en terapias en regeneración de tejidos dentales.

 


Palabras clave


Células troncales de la papila apical (SCAP), dientes permanentes inmaduros, medicina regenerativa, ingeniería tisular, odontología.

Texto completo:

PDF HTML

Referencias


Kolios G, Moodley Y. Introduction to Stem Cells and Regenerative Medicine. Respiration 2012 Dec;85(1):3-10.

Raman V Nelakanti, Nigel G Kooreman, Joseph C Wu. Teratoma formation: a tool for monitoring pluripotency in stem cell research. Current protocols in stem cell biology 2015 Feb 2,;32:4A.817.

Ullah I, Subbarao RB, Rho GJ. Human mesenchymal stem cells - current trends and future prospective. Bioscience reports 2015;35(2).

Zhao Q, Ren H, Han Z. Mesenchymal stem cells: Immunomodulatory capability and clinical potential in immune diseases. Journal of Cellular Immunotherapy 2016 Mar;2(1):3-20.

Egusa H, Sonoyama W, Nishimura M, Atsuta I, Akiyama K. Stem cells in dentistry - Part II: Clinical applications. Journal of Prosthodontic Research 2012;56(4):229-248.

Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006;8(4):315-317.

Germain L, De Berdt P, Vanacker J, Leprince J, Diogenes A, Jacobs D, et al. Fibrin hydrogels to deliver dental stem cells of the apical papilla for regenerative medicine. Regenerative Medicine 2015;10(2):153-167

Vanacker J, Viswanath A, De Berdt P, Everard A, Cani PD, Bouzin C, et al. Hypoxia modulates the differentiation potential of stem cells of the apical papilla. Journal of endodontics 2014 Sep;40(9):1410

Yang J, Yuan G, Chen Z. Pulp Regeneration: Current Approaches and Future Challenges. Frontiers in physiology 2016;7:58.

Zhang N, Chen B, Wang W, Chen C, Kang J, Deng SQ, et al. Isolation, characterization and multi-lineage differentiation of stem cells from human exfoliated deciduous teeth. Molecular Medicine Reports 2016 Jul;14(1):95-102.

Sonoyama W, Liu Y, Yamaza T, Tuan RS, Wang S, Shi S, et al. Characterization of the Apical Papilla and Its Residing Stem Cells from Human Immature Permanent Teeth: A Pilot Study. Journal of Endodontics 2008;34(2):166-171.

Beyer Nardi N, da Silva Meirelles L. Mesenchymal stem cells: isolation, in vitro expansion and characterization. Handbook of experimental pharmacology 2006(174):249.

Prateeptongkum E, Klingelhöffer C, Morsczeck C. The influence of the donor on dental apical papilla stem cell properties. Tissue & cell 2015 Aug;47(4):382-388.

Ding G, Wang W, Liu Y, An Y, Zhang C, Shi S, et al. Effect of cryopreservation on biological and immunological properties of stem cells from apical papilla. Journal of cellular physiology 2010 May;223(2):n/a.

Mao JJ, Kim SG, Zhou J, Ye L, Cho S, Suzuki T, et al. Regenerative endodontics: barriers and strategies for clinical translation. Dental clinics of North America 2012 Jul;56(3):639.

Huang GT. Dental pulp and dentin tissue engineering and regeneration: advancement and challenge. Frontiers in bioscience (Elite edition) 2011;3(2):788-800.

Wang X, Thibodeau B, Trope M, Lin LM, Huang GT-. Histologic Characterization of Regenerated Tissues in Canal Space after the Revitalization/Revascularization Procedure of Immature Dog Teeth with Apical Periodontitis. Journal of Endodontics 2010;36(1):56-63.

Nanci A, Ten AR. Ten Cate´s Oral Histology, development, structure and function. Editorial Mosby. 6 ed. 2003.p.141-190

Shi S, Bartold PM, Miura M, Seo BM, Robey PG, Gronthos S. The efficacy of mesenchymal stem cells to regenerate and repair dental structures. Orthodontics & craniofacial research 2005 Aug;8(3):191-199.

Lee B, Moon J, Chang H, Hwang I, Oh W, Hwang Y. A review of the regenerative endodontic treatment procedure. Restorative dentistry & endodontics 2015 Aug;40(3):179-187.

Hemmat S, Lieberman D, Most S. An Introduction to Stem Cell Biology. Facial plast Surg 2010 Oct;26(5):343-349

Bakopoulou A, About I. Stem Cells of Dental Origin: Current Research Trends and Key Milestones towards Clinical Application. Stem Cells International 2016;2016:1-20.

Schuurs AHB, Gruythuysen RJM, Wesselink PR. Pulp capping with adhesive resin‐based composite vs. calcium hydroxide: a review. Dental Traumatology 2000 Dec;16(6):240-250.

Zhou H, Shen Y, Wang Z, Li L, Zheng Y, Häkkinen L, et al. In vitro cytotoxicity evaluation of a novel root repair material. Journal of endodontics 2013 Apr;39(4):478-483.

Egusa H, Sonoyama W, Nishimura M, Atsuta I, Akiyama K. Stem cells in dentistry--part I: stem cell sources. Journal of Prosthodontic Research 2012 July;56(3):151-165.

Lee J, Seo S. Biomedical Application of Dental Tissue-Derived Induced Pluripotent Stem Cells. Stem Cells International 2016;2016:1-7.

Martens W, Bronckaers A, Politis C, Jacobs R, Lambrichts I. Dental stem cells and their promising role in neural regeneration: an update. Clin Oral Invest 2013 Dec;17(9):1969-83.

Volponi AA, Pang Y, Sharpe PT. Stem cell-based biological tooth repair and regeneration. Trends in Cell Biology 2010;20(12):715-722.

29. Duncan HF, Smith AJ, Fleming GJP, Cooper PR. Epigenetic modulation of dental pulp stem cells: implications for regenerative endodontics. International Endodontic Journal 2016 May;49 (5):431-446.

Gopinathan G, Kolokythas A, Luan X, Diekwisch TGH. Epigenetic Marks Define the Lineage and Differentiation Potential of Two Distinct Neural Crest-Derived Intermediate Odontogenic Progenitor Populations. Stem Cells and Development 2013 Jun 15,;22(12):1763-1778.

Robey PG, Kuznetsov SA, Ren J, Klein HG, Sabatino M, Stroncek DF. Generation of clinical grade human bone marrow stromal cells for use in bone regeneration. Bone 2015 Jan;70:87-92.




ISSN: 2007-9052

Indexada en Latindex.

Indexada en Google académico.

Indexada en INFOMED - Cuba.

Http:www.remexesto.com

 


Contador y estadísticas gratis para su sitio web en www.motigo.com